Pep Guardiola's side began the defence of their title with an emphatic 5-0 away win over West Ham, although should face more resistance against the team who knocked them out of last season's Champions League.
Latest odds
Nevertheless, they remain favourites with bet365 to make a major statement by coming out on top in their first home game of the Premier League season.
Spurs finished last season with six consecutive league defeats on the road, but are available at to pull off a shock win at the home of the champions.
Just one of the last 19 encounters between this pair has resulted in a draw, but you can get odds of on them cancelling each other out here.
Team news
Fernandinho and Joao Cancelo will face late fitness tests, while Benjamin Mendy and Leroy Sane are long term absentees.Dele Alli, Juan Foyth and Ryan Sessegnon are all injured, with Ben Davies doubtful and Son Heung-min suspended.
Preview
Although many will be earmarking this fixture as one of the few realistic banana skins for the Citizens, their record against the guests is actually fairly convincing - winning each of the last four in the league.
Considering the players missing for Mauricio Pochettino's team, it is hard to see them breaking that cycle on Saturday.
In fact, the hosts usually waste little time in seeing off this opposition, taking the lead within 22 minutes in five of the last six encounters.
Predictions
With Tottenham having fallen behind within 10 minutes in three of their last four matches, odds of 20/21 (1.95) are surely worth backing on Manchester City leading at both half-time and full time for their seventh encounter in nine one home turf.
All odds correct at time of publish. Please gamble responsibly.